Autism Research


Welcome to the Autism Medication Guidelines and Research Section Of AutismReach.
Note to Prescribers: Read This Important Medication Update Regarding Medication Use in Autistic Individuals

Table of Contents:

 Note to Prescribers:

NIMH (The National Institute of Health and Clinical Excellence) who produces clinical guidelines for the NHS (National Health Service) has released the following statement on SSRI use in individuals with Autism:

“There is no evidence that selective serotonin reuptake inhibitors (SSRIs) are effective as a treatment for children with autism. In fact, there is emerging evidence that they are not effective and can cause harm. As such, selective serotonin reuptake inhibitors cannot be recommended as a treatment for children with autism at this time.”

Currently, we only have two medication agents that have strong clinical data for use in individuals with Autism Spectrum Disorder (Risperidone and Aripiprazole) which treats Irritability associated with Autism.

SSRI’s are commonly prescribed to autistic individuals, but clinical trials have started to prove that these medications are not effective and cause harm (such as self-injurious behaviors, irritability, and insomnia) in pediatric patients.

For more information on medication treatment in autistic individuals, I have compiled a list of guidelines, and clinical trials for individual agents below. Please use this page as a resource when working with any of your patients with Autism Spectrum Disorder.


Format: [Medication Name][Year-Month] – Trial Name – [Full Trial/Abstract]

  If you find more research and would like to add it to this list, email me at: MaxLeePharmD@gmail.com


Autism Prevalence 

[2015-11] [1 in 45 children aged 3 to 17]  Estimated Prevalence of Autism and Other Developmental Disabilities Following Questionnaire Changes in the 2014 National Health Interview Survey [Full Clinical Study]

[2014-03] [1 in 45 children in New Jersey] New Jersey Autism Prevalence Rates

[2014-03] [1 in 68 children] CDC Estimates 1 in 68 children has been identified with Autism Spectrum Disorder

 

Official Guidelines for Autism Spectrum Disorder

Official Guidelines/Recommendations

[2014-02] Practice Parameter for the Assessment and Treatment of Children and Adolescents With Autism Spectrum Disorder [Full Guidelines]

[2012-08] Psychotropic Medications in Children with Autism Spectrum Disorders: A systematic Review and Synthesis for Evidence-Based Practice

 

Pharmacologic Research in Autism Spectrum Disorder – [Systematic Reviews and Meta Analyses]

[2014-08] The Use of Medications Approved for Alzheimer’s Disease In Autism Spectrum Disorder: A Systematic Review

[2012-08] Psychotropic Medications in Children with Autism Spectrum Disorders: A systematic Review and Synthesis for Evidence-Based Practice

[2012-09] Pharmacologic Treatments for the Behavioral Symptoms Associated with Autism Spectrum Disorders Across the Lifespan 

[2012-05] Pharmacologic Treatment of Repetitive Behaviors in Autism Spectrum Disorders: Evidence of Publication Bias

[2011-04] A Systematic Review of Medical Treatments for Children With Autism Spectrum Disorders

[2010-05] Selective Serotonin Reuptake Inhibitors (SSRI’s) for Autism Spectrum Disorders – The National Institute for Health and Care Excellence  [Full Article]

[2010-04] Safety and Tolerability of Aripiprazole in the Treatment of Irritability Associated With Autistic Disorder in Pediatric Subjects (6-17 Year Old):Results From a Pooled Analysis of 2 Studies

 

Alpha-2 Agonist – Medication Research

[Clonidine] [1992-10] – Clonidine treatment of hyperactive and impulsive children with autistic disorder. [Abstract Only]

[Clonidine] (Transdermal) [1992-03] – A double-blind, placebo-controlled study of the efficacy of transdermal clonidine in autism [Abstract Only]

[Guanfacine] [2008-08] – Guanfacine in children with autism and/or intellectual disabilities [Abstract Only]

Antipsychotic Medication Research In Autism Spectrum Disorder

[Aripiprazole] [2015-09] – Aripiprazole for treating irritability in children & adolescents with autism: a systematic review

[Aripiprazole] [2010-04] Safety and Tolerability of Aripiprazole in the Treatment of Irritability Associated With Autistic Disorder in Pediatric Subjects (6-17 Year Old):Results From a Pooled Analysis of 2 Studies

[Aripiprazole] [2009-12] – Aripiprazole in the Treatment of Irritability in Children and Adolescents With Autistic Disorder [Full Clinical Trial]

[Aripiprazole] [2009-11] – A Placebo-Controlled, Fixed-Dose Study of Aripiprazole in Children and Adolescents With Irritability Associated With Autistic Disorder [Abstract Only]

[Haloperidol] [1989-01] – Long-Term Efficacy of Haloperidol in Autistic Children: Continuous versus Discontinuous Drug Administration [Abstract]

[Olanzapine] [2006-10] – A Double-Blind Placebo-Controlled Pilot Study of Olanzapine in Childhood/Adolescent Pervasive Developmental Disorder [Abstract Only]

[Risperidone] [2005-06] – Risperidone for the Core Symptom Domains of Autism [Full Clinical Trial]

[Risperidone] [2004-10] – Risperidone in the treatment of disruptive behavioral symptoms in children with autistic and other pervasive developmental disorders [Full Clinical Trial]

[Risperidone] [2002-08] – Risperidone In Children With Autism and Serious Behavioral Problems [Full Clinical Trial]

[Risperidone & Haloperidol] [2008-02] – Risperidone versus haloperidol in children and adolescents with AD [Abstract]

Mood Stabilizer Medication Research in Autism Spectrum Disorder

[Divalproex] [2009-12] – Divalproex Sodium vs Placebo For The Treatment of Irritability in Children and Adolescents with Autism Spectrum Disorders

[Divalproex] [2005-05] – Divalproex Sodium Vs. Placebo In The Treatment of Repetitive Behaviors In Autism Spectrum Disorder

[Lamotrigine] [2001-04] – Lamotrigine Therapy for Autistic Disorder: A Randomized, Double-Blind, Placebo-Controlled Trial

[Levetiracetam] [2006-11] – Levetiracetam versus placebo in children and adolescent autism: a double-blind placebo-controlled study [Abstract]

 

Antidepressants – Medication Research

Tricyclic Antidepressant Research In Autism Spectrum Disorder

[Clomipramine] [2001-08] – Clomipramine & Haloperidol – Clomipramine versus Haloperidol in the treatment of Autistic Disorder: A double-blind, placebo-controlled, crossover study [Abstract Only]

[Clomipramine] [1996-04] – A Pilot Study of Clomipramine in Young Autistic Children [Abstract Only]

[Clomipramine] [1993-06] – A Double-blind Comparison of Clomipramine, Desipramine, and Placebo in the Treatment of Autistic Disorder [Abstract Only]

Norepinephrine Reuptake Inhibitor Medication Research

[Atomoxetine] [2006-10] – Atomoxetine for hyperactivity in autism spectrum disorders: placebo-controlled crossover pilot trial [Abstract Only]

Selective Serotonin Reuptake Inhibitor Research In Autism Spectrum Disorder

[Citalopram] [2009-06] – Lack of Efficacy of Citalopram in Children With Autism Spectrum Disorders and High Levels of Repetitive Behaviors [Full Clinical Trial]

[Fluoxetine] [2011-09] – A Double-Blind Placebo Controlled Trial of Fluoxetine for Repetitive Behaviors and Global Severity in Adult Autism Spectrum Disorder [Full Clinical Trial]

[Fluoxetine] [2004-12] – A Placebo Controlled Trial of Liquid Fluoxetine on Repetitive Behaviors in Childhood and Adolescent Autism [Full Clinical Trial]

[Fluvoxamine] [2005-06] – Fluvoxamine and Functional Polymorphism in a Serotonin Transporter Gene on Childhood Autism [Abstract Only]

[Fluvoxamine] [1996-11] – A Double-blind, Placebo-Controlled Study of Fluvoxamine in Adults With Autistic Disorder [Abstract Only]

 

[2012-05] Pharmacologic Treatment of Repetitive Behaviors in Autism Spectrum Disorders: Evidence of Publication Bias [Full Article]

[2010-05] Selective Serotonin Reuptake Inhibitors (SSRI’s) for Autism Spectrum Disorders – The National Institute for Health and Care Excellence  [Full Article]

Psychostimulant Medication Research in Autism Spectrum Disorder

[Methylphenidate] [2005-11] – Randomized, double-blind, placebo-controlled, crossover trial of methylphenidate in children with hyperactivity associated with pervasive developmental disorders [Full Clinical Trial]

[Methylphenidate] [2000-06] – Efficacy of methylphenidate among children with autism and symptoms of attention-deficit hyperactivity disorder [Abstract Only]

[Methylphenidate] [1995-11] – Use of methylphenidate in the treatment of children with autistic disorder. Journal of Autism and Developmental Disorders [Full Clinical Trial]

 

Miscellaneous Medication Research In Autism Spectrum Disorder

[Amantadine][2001-06] – Double-blind, Placebo-Controlled Study of Amantadine Hydrochloride in the Treatment of Children with Autistic Disorder [Abstract]

[Bumetanide] [2012-12] – A Randomized Controlled Trial of Bumetanide in the Treatment of Autism in Children

[Donepezil] [2001-06] – Donepezil hydrochloride: A Double-blind study in Autistic Children [Full Clinical Trial]

[Memantine] [2012-09] – Memantine as adjunctive treatment to Risperidone in children with autistic disorder: a randomized, double-blind, placebo-controlled trial

[Oxytocin] [2012-12] – Intranasal oxytocin versus placebo in the treatment of adults with autism spectrum disorders: a randomized controlled trial

 

Diet In Autism Spectrum Disorder – Clinical Research

[2011-12] – Effect of a vitamin/mineral supplement on children and adults with autism

[2008-07] Development of double blind gluten and casein free test foods for use in an autism dietary trial [Abstract Only]

[2007-02] Omega-3 Fatty Acids Supplementation in Children with Autism: A Double-blind Randomized, Placebo-controlled Pilot Study [Abstract Only]

[2006-03] The Gluten-Free, Casein-Free Diet In Autism: Results of A Preliminary Double Blind Clinical Trial

 

 

Other Research

[2013-12] Use of Selective Serotonin Reuptake Inhibitors during Pregnancy and Risk of Autism

[2014-08] Measles-mumps-rubella vaccination timing and autism among young african american boys; a reanalysis of CDC data

[2010-10] HEPATITIS B VACCINATION OF MALE NEONATES AND AUTISM DIAGNOSIS, NHIS 1997–2002

[2002-11] A Population-Based Study of Measles, Mumps, and Rubella Vaccination and Autism

[1998-02] Andrew Wakefield’s Original Vaccine Paper From 1998 Linking Vaccines to Autism Spectrum Disorder

Research To ASD Links

Research Link 1

Research Link 2

Autism Research Report – Top Authors and countries